The octapeptide SNAP-8 is an elongation of the aforementioned Argireline® peptide. It imitates the N-terminal end of SNAP-25, thereby giving SNAP-25 competition for its place in the SNARE complex. In doing so, SNAP-8 reduces the formation of SNAP-25. By destabilizing the SNARE complex ever so slightly, the vesicle is unable to efficiently release neurotransmitters. In this state, the ability to contract muscles declines and lines and wrinkles are effectively thwarted.
As you may already know, aging in the face is related to changes in the conformation of the collagen triple helix, elastin polypeptide degradation, and dysfunction in the skin’s lipidic matrix packing. By curbing muscle contraction, these problematic changes and dysfunction can be circumvented.
Muscles contract when a vesicle releases a neurotransmitter.
Before a neurotransmitter can be releasd at the synapsis, the SNARE (SNAp REceptor) complex must come into play. SNARE consists of the proteins VAMP, Syntaxin, and SNAP-25 (SyNaptosomal Associated Protein). The SNARE complex behaves as a trap that seizes vesicles and connects them to the membrane, stimulating neurotransmitter release.